Nurse Jackie Peyton faces her biggest challenge yet as the whole truth about her addiction is seemingly out to everyone. The stakes have never been higher and the question is, can the world's toughest nurse save herself?

Jackie Peyton, a strong-willed and brilliant but very flawed emergency room nurse. This season, Jackie comes to realize that both karma and sobriety can be a pain. In addition to finally confronting her addiction, Jackie's street smarts and sardonic wit are tested even further by an ambitious new hospital administrator determined to run a tight ship and keep Jackie in line.

Jackie realizes sobriety is the ultimate cover for getting high, and now she's saving lives at work, taking care of her kids, and her boyfriend is loving the new her. She's got everyone fooled, but what goes up must come down.

Nicky is a seasoned master of misdirection who becomes romantically involved with novice con artist Jess. As he's teaching her the tricks of the trade, she gets too close for comfort and he abruptly breaks it off. Three years later, the former flame, now an accomplished femme fatale, shows up in Buenos Aires in the middle of the high stakes race-car circuit. In the midst of Nicky's latest, very dangerous scheme, she throws his plans for a loop, and...